RESEARCH TECHNICIAN IIDescription:
Job Description
A RESEARCH TECHNICIAN position in the functional Alzheimer's Disease group is available in Tanzi laboratory at Massachusetts General Hospital and Harvard Medical School. Working independently, under the direction of Dr. Can Zhang heading up in Dr. Rudolph Tanzis laboratory, this candidate will focus on the characterization of the mechanistic causes of Alzheimers disease, with the ultimate goal of identifying novel therapeutic strategies for AD and intervening targets for aging. This candidate will work together with other laboratory members to carry out experiments that functionally identify and characterize genes that confer increased risk of Alzheimers disease. Specifically the experiments will focus on elucidating the mechanism of APP metabolism alteration on the cellular and molecular levels using cell and animal-based models. In addition, this candidate will investigate novel pharmacological agents structurally related to curcumin (diferulomethane) which modulate the processing of APP and the pathogenesis of Alzheimer's disease. This candidate is expected to be highly motivated, enthusiastic and organized. In addition, technical skills, attention to detail, and excellent communication skills are a must (see more in Qualifications).
Major duties:
Executes protocols of routine and non-routine experiments
Assists PI with determining the most suitable methodology
Performs basic design and modification of protocols
Sets up, prepares and executes both routine and non-routine experiments
Calculates, transcribes, analyzes data, and interprets results
Prepares lab reagents, chemicals, instruments and equipment, and orders common laboratory reagents and general maintenance of the laboratory
Participates in the design of experiments or field work
Organizes and summarizes acquired data, using scientific and statistical techniques, and then presents in the format of graphs, charts, tables, illustrations and slides through PPT, EXCEL and /or WORD.
Maintains and updates files, databases, records, and/or other documents
Precisely organizes and accurately maintains written records of experimental procedures including Lab notebook
Organizes and/or drafts material for the preparation of papers, manuscripts, or other documents resulting from data generated in research projects for publication and/or presentation
Prepares and presents reports to PI
Participates in upkeep of lab, performs basic maintenance on laboratory equipment and reports equipment requiring advanced repair.
Qualifications
Minimum of a Bachelors degree in Cell Biology, Molecular Biology, or related field required
Minimum of 1 year of directly related experience involving neuro-degeneration and Alzheimer's disease ; More than 1 year desirable. Preferably in the context of an independent project showing skills in critical thinking and data analyzing
Expertise in molecular biology: polymerase chain reaction; transformation; DNA/RNA/protein extraction and preparation; agorose electrophoresis; Western blotting analysis; , fluorescence microscopy; and ELISA
Expertise in cellular biology work: maintenance of cell lines; and construction of new cell lines with specific antibiotic resistance
Excellent communication skills and the ability to interact professionally with PI and colleagues
Excellent critical thinking skills and attention to detail with the ability to resolve technical problems
Ability to work independently and as a team member
High degree of computer literacy
Qualifications:
Company Profile:
Founded in 1811, Massachusetts General Hospital is the third-oldest general hospital in the country, and the oldest and largest in New England. The 907-bed world-renowned medical center offers sophisticated diagnostic and therapeutic care in virtually every specialty and subspecialty of medicine and surgery. The largest teaching hospital of Harvard Medical School, MGH is on the cutting edge of patient care, research and medical education. It is the largest nongovernment employer in the city of Boston, with more than 21,500 employees.
MGH is among the leading medical institutions continuously recognized by U.S. News & World Report's annual honor roll of America's best hospitals. In 2009, MGH ranked fifth nationally, with MGH Psychiatry ranking first in that specialty for the 14th consecutive year. MGH has been named to the list since the publication began conducting the survey in 1990.
In 2008, MGH again was named a Magnet hospital by the American Nurses Credentialing Center, a subsidiary of the American Nurses Association. The Magnet Recognition Program recognizes health care organizations that provide the best in nursing care and to uphold the tradition of excellence in professional nursing practice. MGH was the first Massachusetts hospital to earn the Magnet designation in 2003.
MGH has repeatedly been named an employer of choice. Most recently, it was named to The Globe 100, a list of the top employers in Massachusetts compiled by The Boston Globe. The hospital has also earned a spot on Conceive magazine's 2009 list of the Top 50 Workplaces for Prospective Parents.
A career with MGH means you'll be part of a rich legacy of providing top-quality patient care and an integral part of ensuring that our success continues. Located in Boston, MGH is accessible by several MBTA lines. Our benefits and perks are outstanding and include health/dental insurance, a retirement plan, 403b, paid time off, tuition reimbursement, childcare center and a fitness center. There is only one MGH! For more information, please visit us at .
Massachusetts General Hospital is an Equal Employment/Affirmative Action Employer.
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